张元特聘研究员（PI）

办公电话:

电子邮件:

mczhang@scut.edu.cn

2019 -至今 华南理工大学 特聘研究员

2016-2019 美国罗德岛大学 助理教授

2013-2016 美国麻省理工学院 博士后

2009-2013 美国北卡罗莱纳大学教堂山分校分子药剂系 博士

2007-2009 北京大学药剂系 硕士

2003-2007 北京大学药学专业 学士

生物制药与制药工程

主要从事纳米药物和基因递送，免疫治疗和疫苗开发等方面的研究。多个科研项目得到了美国NIH等政府项目和基金会的资助。在Nature Communications, Biomaterials, Journal of Controlled Release, Molecular Therapy, ACS Nano, Nanoscale, Pharmaceutical Research, Molecular Pharmaceutics 等期刊发表论文20篇，其中一作9篇，通讯作者3篇，专著2部。美国及国际发明专利2项，中国发明专利1项。

代表性论文：

1. Yuan Zhang^*, Xin Bush, Bingfang Yan, Yue Zhang, Justin A.Chen, Gemcitabine nanoparticles promote antitumor immunity against melanoma. Biomaterials, 2019, 189,48-59. (^*通讯作者，I区，IF=10.273)

2. Yuan Zhang^*, Na Li, Heikyung Suh, Darrell J. Irvine^*, Nanoparticle anchoring targets immune agonists to tumors enabling anti-tumor efficacy without systemic toxicit. Nature Communications, 2018,9 (1): 6. (^*共同通讯作者，I区，IF=11.878)

3. YuanZhang, Lei Peng, Russell J.Mumper, Leaf Huang^*, Combinational delivery of c-myc siRNA and nucleoside analogs in a single, synthetic nanocarrier for targeted cancer therapy. Biomaterials, 2013,34 (33): 8459-8468. (I区，IF=10.273)

4. Jing Yao^#, YuanZhang^#, Srinivas Ramishetti, Yuhua Wang, Leaf Huang ^*, Turning an antiviral into an anticancer drug: nanoparticle delivery of acyclovir monophosphate. Journal of Controlled Release, 2013, 170 (3): 414-420. (^#共同第一作者, I区，IF=7.901)

5. YuanZhang, Nicole M. J. Schwerbrock, Arlin B.Rogers, William Y.Kim, Leaf Huang^*, Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Molecular Therapy, 2013, 21 (8): 1559-1569. (I区，IF=8.402)

6. YuanZhang, William Y.Kim, Leaf Huang*, Systemic delivery of gemcitabine triphosphate via LCP nanoparticles for NSCLC and pancreatic cancer therapy. Biomaterials, 2013, 34 (13): 3447-58. (I区，IF=10.273)

7. Yuan Zhang, Andrew Satterlee, Leaf Huang. In vivo gene delivery by nonviral vectors: overcoming hurdles? Molecular Therapy, 2012, 20 (7): 1298-304. (I区，IF=8.402)