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关于举行瑞士洛桑联邦理工大学Li Tang博士学术报告会的通知

报告题目:Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine

报 告 人:Li Tang, Ph.D. Assistant Professor(洛桑联邦理工大学)

主 持 人:熊梦华 教授

报告时间:2019122日(星期一)15:00

报告地点:大学城校区B2-101会议室

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                               生物医学科学与工程学院

                                      20191119

附件:

内容摘要:A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. We devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigens and adjuvants together with a tracelessly responsive linker-monomer. Peptide-based neoanti-gens with diverse sequences and structures could be co-polymerized with molecular adjuvants to form PNEs of high loading capacity for vaccine delivery without adding any carriers. The redox-responsive PNEs with controlled molecular weights and sizes efficiently targeted and accumulated in draining lymph nodes, and greatly promoted the antigen capture and cross-presentation by professional antigen presenting cells. Mice immunized with PNEs showed markedly enhanced antigen-specific T cell response and the protective immunity against the tumor cell challenge. I will also discuss our recent discovery of a new immunotherapy that reinvigorates terminally exhausted tumor infiltrating lymphocytes leading to eradication of a majority of treated solid tumors and durable cures in mouse models.

报告人简介:Li Tang received his B.S. in Chemistry from Peking University in China in 2007, and his Ph.D. in Materials Science and Engineering from University of Illinois at Urbana-Champaign, USA, in 2012, under the supervision of Prof. Jianjun Cheng. He was an Irvington Postdoctoral Fellow in the laboratory of Prof. Darrell Irvine at Massachusetts Institute of Technology during 2013-2016. He joined the faculty of Institute of Bioengineering, and Institute of Materials Science & Engineering, at École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, as a Tenure-Track Assistant Professor in 2016. His research focuses on modulating the immune system using smart biomaterials to develop novel vaccines and immunotherapies. Dr. Tang is the recipient of 2018 European Research Council (ERC) starting grant, Nano Research Young Innovator Award (NR 45 under 45 in the world), and Irvington Postdoctoral Fellowship from Cancer Research Institute.