美国路易斯安那理工大学Yuri Lvov教授：Biomedical clay nanocomposites with sustained drug release

 地点：材料科学与工程学院25号楼331会议室

 报告摘要：
        Halloysite alumosilicate nanotubes with a 15 nm lumen, 50 nm  external diameter, and length of 1-1.5 µm have been developed as an  entrapment system for loading, storage, and controlled release of  chemical agents (anticorrosion, flame-retardancy, biocides, drugs and  proteins). Studies to enable the control of release rates from hours to  days and months are being undertaken. By the formation of nanoshells  over the nanotubes or by creation of smart caps at the tube ends it is  possible to extend release rate. Halloysite forms stable aqueous  colloids and is well admixable with polar and low polar plastics.  Protective halloysite coatings and a self-healing approach have been  tested for repair mechanisms through response activation by external  impacts. Doping loaded clay nanotubes into polymeric matrix  (polyurethane, polypropylene, siloxane, epoxy, etc.) provides sustained  inhibitors’ release and this ceramic “skeleton” is enhancing the  composite strength. Doping clay nanotubes into paint at 3-5 wt. %  provides sustained release of anticorrosion agents resulting in 2-times  longer metal protection as well as in 50-100 % increase in the coating  strength and adhesivity. As well, double in flame-retardancy was  reached. Biocompatible halloysite nanotubes allow for 10 wt. % loading  with drugs and proteins preserving their activity and providing 10-50  hrs release time. Halloysite nanotubes are available in thousands of  tons, and remain sophisticated and novel nanomaterials which can be used  as smart nano-containers. Halloysite is also a green material and due  to the fact that it is a natural product will not add risk to the  environment.