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关于举行德国马普胶体与界面研究所Kerstin G. Blank 教授学术报告的通知

日期:2018-10-18

Molecular Force Sensors: from molecular mechanisms towards applications in biology and materials science

报 告 人:Kerstin G. Blank 教授, Max Planck Institute of Colloids and Interfaces

报告题目:Molecular Force Sensors: from molecular mechanisms towards applications in biology and materials science

报告时间:2018年10月22日(星期一)10:00

报告地点:华南理工大学大学城校区B2-101会议室

生物医学材料与工程教育部重点实验室

 2018年10月18日


报告人简介:Kerstin  Blank studied Biotechnology at the University of Applied Sciences in  Jena and obtained her diploma in 2000. After 3 years as a project  manager in Industry, she returned to Academia. Under supervision of Prof  Hermann Gaub at Ludwig-Maximilians Universität in Munich she earned her  PhD in Biophysics in 2006. After two short postdoctoral stays with Prof  Andrew Griffiths (Université de Strasbourg) and Prof Johan Hofkens  (Katholieke Universiteit Leuven), she became assistant professor at  Radboud University in Nijmegen in 2009. In 2014, she moved to the Max  Planck Institute of Colloids and Interfaces where she holds the position  of a Max Planck Research Group Leader. Her research interests combine  her background in biochemistry and single molecule biophysics with the  goal of developing molecular force sensors for biological and materials  science applications.

Abstract:Biological  systems are highly sophisticated smart materials. They are  stimuli-responsive and possess impressive self-reporting and  self-healing properties. They are consequently an important source of  inspiration for materials scientists who aim to implement these  properties in synthetic and biomimetic materials. In this context, we  are specifically interested in (bio)molecules that act as molecular  force sensors. In biological systems, these sensors detect a mechanical  stimulus and convert it into a biochemical signal. Mimicking their  natural counterparts, a number of different force sensors have been  designed and synthesized in recent years that generate an optical output  (fluorescence). Following a calibration of their mechanical properties,  these artificial force sensors can report on molecular forces in situ  in a highly sensitive manner. In this lecture, I will summarize our  efforts towards designing and characterizing molecular force sensors,  focusing on two classes of force sensors that are based on fundamentally  different molecular mechanisms: The first class utilizes biological  molecules that form thermodynamically stable, non-covalent interactions,  such as short, double-stranded DNA duplexes or coiled coil  interactions. These force sensors report on forces in the range between  10-200 piconewton, making them ideal candidates for applications in  biological systems. The second class is based on covalent bonds, which  require forces above 400 pN to become activated. One example is the  mechanical activation of triazoles as they are formed in a typical  ‘click chemistry’ reaction. With these molecular force sensors at hand,  our goal is to utilize these sensors for detecting cellular traction  forces or for visualizing force propagation pathways in polymeric  materials.

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