Name: Xu Jin
Introduction:
My lab is interested in the development of the immune system and the function of immune cells on tissue regeneration. We mainly take the unique advantages of zebrafish to tackle questions which are difficult to be answered in other animal models. Zebrafish produces large number of embryos and their embryos are transparent. These advantages make zebrafish an excellent model for forward genetic study and optic observation/manipulation. By taking these unique advantages, we expect to do innovative research.
Title: Professor
Education:
1998-2002 B.S. Nanjing University
2002-2008 Ph.D. National University of Singapore, Institute of Molecular and Cell Biology
Working Experiences:
2008-2017 Hong Kong University of Science and Technology
Research Fields:
Immunology, Development and Regeneration
Achievements:
Main publications:
1.Xu J*, Wang TN*, Wu Y, Jin W, Wen ZL. Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine. Dev Cell. 2016 Jul 25; 38(2):214-22. (*equal contribution)
2.Xu J*, Zhu L*, He S, Wu Y, Jin W, Yu T, Qu JY, Wen ZL. Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish. Dev Cell. 2015 Sep 28; 34(6):632-41. (*equal contribution)
3.Xu J, Du L, Wen ZL. Myelopoiesis during zebrafish early development. J Genet Genomics. 2012 Sep 20; 39(9):435-42. (review)
4.Du LS*, Xu J*, Li XL, Ma N, Liu YM, Peng JR, Osato M, Zhang WQ, and Wen ZL. (2011) Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis. Development. 2011 Feb; 138(4): 619-29. (*equal contribution)
5.Jin H*, Xu J*, and Wen ZL.(2007) Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development. Blood. 2007 Jun 15; 109(12): 5208-14. (* equal contribution)
Other publications:
1.Tian Y, Xu J, Feng S, He S, Zhao S, Zhu L, Jin W, Dai Y, Luo L, Qu JY, Wen Z. The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells. J Exp Med. 2017 Nov 6;214(11):3347-3360.
2.Yu T, Guo W, Tian Y, Xu J, Chen J, Li L, Wen Z. Distinct regulatory networks control the development of macrophages of different origins in zebrafish. Blood. 2017 Jan 26;129(4):509-519.
3.Jin H, Huang Z, Chi Y, Wu M, Zhou R, Zhao L, Xu J, Zhen F, Lan Y, Li L, Zhang W, Wen ZL, Zhang Y. cMyb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish. Blood. 2016 Jul 21; 128(3):415-26.
4.Wei Y, Xu J, Zhang W, Wen ZL, Liu F. RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development. 2016 Jun 15; 143(12):2103-10.
5.Zeng Y, Yan B, Xu J, Sun Q, He S, Jiang J, Wen ZL, Qu JY. In Vivo nonlinear optical imaging of immune responses: tissue injury and infection. Biophys J. 2014 Nov 18; 107(10):2436-43.
6.Li X, Lan Y, Xu J, Zhang WQ, Wen ZL. SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish. Development.2012 Dec 1; 139(23):4321-9.
7.Zeng Y, Xu J, Li D, Li L, Wen ZL, Qu JY. Label-free in vivo flow cytometry in zebrafish using two-photon autofluorescence imaging. Opt Lett. 2012 Jul 1; 37(13):2490-2.
8.Jin H, Li L, Xu J, Zhen F, Zhu L, Liu PP, Zhang MJ, Zhang WQ, Wen ZL. Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression. Blood. 2012 May 31; 119(22):5239-49.
9.Li L, Jin H, Xu J, Shi YQ, and Wen ZL. (2011) Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis. Blood.2011 Jan 27;117(4): 1359-69.
10.Jin H, Sood R, Xu J, Zhen FH, Liu PP, andWen ZL. (2009) Hematopoietic stem cells manifest distinct differentiation output in the zebrafish VDA and PBI.Development. 2009 Feb; 136(4): 647-54.
11.Liu YM, Du LS, Osato M, Teo EH, Qian F, Jin H, Zhen FH, Xu J, Guo L, Huang HH, Chen J, Geisler R, Jiang YJ, Peng JR and Wen ZL. (2007) The zebrafish udu gene encodes a novel nuclear factor and is essential for primitive erythroid cell development. Blood.2007 Jul 1;110(1): 99-106.
12.Qian F, Zhen FH, Xu J, Huang M, Li WY, and Wen ZL. (2007) Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesis. PLoS Biology. 2007 May; 5(5): e132.
13.Jin H*, Xu J*, Qian F, Du LS, Tan CY, Lin ZX, Peng JR, and Wen ZL.(2006) The 5’ zebrafish scl promoter targets transcription to the brain, spinal cord, hematopoietic and endothelial progenitors. Developmental Dynamics. 2006 Jan; 235(1): 60-7. (*equal contribution)
Phone: 13809241844
E-mail: xujin@scut.edu.cn
