实验室

王键教授   神经生物学实验室

华南理工大学博士生导师


电子邮箱:jwangsc@scut.edu.cn

教育/工作经历

2016-至今,华南理工大学教授,博士生导师

2006-2016,第四军医大学神经生物学教研室,副教授,教授

2004-2006,日本京都大学医学院,研究员

2002-2004,日本京都大学医学院分子免疫学,博士后

2000-2002,第四军医大学神经生物学,博士

1993-2000,第四军医大学神经生物学教研室,助教

1987-1993,第四军医大学医疗专业,本科

实验室研究方向

脊髓损伤修复及神经再生;发育生物学;基因功能解析等

实验室科研成果

发表SCI论文30余篇,主要研究成果发表在Nat Cell Biol、JEM、PNAS、Sci Rep、Mol Neurobiol、Molecular Therapy等一区杂质上。培养硕士博士20余人。曾先后承担或参与国家自然科学基金项目(含重点、面上)及各类省部级科研课题等十余项。

代表性研究论文

Xue Q, Liu L, Wang Y, Fang C, Zhang K, Yu C, Bian G, Song B, Yang A, Ju G, Wang J*  miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a. Sci Rep. Sci Rep 6:26781 

Zhang Q, Bian G, Chen P, Liu L, Yu C, Liu F, Xue Q, Chung SK, Song B, Ju G, Wang J. Aldose Reductase Regulates Microglia/Macrophages Polarization Through the cAMP Response Element-Binding Protein After Spinal Cord Injury in Mice. Mol Neurobiol. 2016, 53:662-676. 

Zhang K, Zheng J, Bian G, Liu L, Xue Q, Liu F, Yu C, Zhang H, Song B, Chung SK, Ju G, Wang J*. Polarized macrophages have distinct roles in the differentiation and migration of embryonic spinal-cord-derived neural stem cells after grafting to injured sites of spinal cord. Molecular Therapy 2015; 23: 1077-91. 

Cheng P, Kuang F, Zhang HF, Ju G, and Wang J*. Beneficial effects of Thymosin β4 on spinal cord injury in the rat. Neuropharmacology 2014, 85: 408-416. 

Yao AH, Liu FF, Chen K, Tang L, Liu L, Zhang K, Yu CY, Bian GL, Guo HM, Zheng JJ Cheng P, Ju G, Wang J*  Programmed Death 1 Deficiency Induces the Polarization of Macrophages/Microglia to the M1 Phenotype After Spinal Cord Injury in Mice. Neurotherapeutics. 2014, 11:636-650.

Deng B, Gao F, Liu FF, Zhao XH, Yu CY, Ju G, Xu LX, Wang J*. Two Monoclonal Antibodies Recognising aa 634-668 and aa 1026-1055 of NogoA Enhance Axon Extension and Branching in Cultured Neurons. PLoS One 2014, 9:e88554.

Wang J, Okazaki IM, Yoshida T, Chikuma S, Kato Y, Nakaki F, Hiai H, Honjo T, Okazaki T. PD-1 deficiency results in the development of fatal myocarditis in MRL mice. Int Immunol 2010, 22:443-452.

Guo J, Yu C, Li H, Liu F, Feng R, Wang H, Meng Y, Li Z, Ju G, Wang J*. Impaired neural stem/progenitor cell proliferation in streptozotocin-induced and  spontaneous diabetic mice. Neurosci Res 2010, 68:329-336. 

Guo J, Li H, Yu C, Liu F, Meng Y, Gong W, Yang H, Shen X, Ju G, Li Z, Wang J*. Decreased neural stem/progenitor cell proliferation in mice with chronic/nonremitting experimental autoimmune encephalomyelitis. Neurosignals 2010, 18:1-8.

Wang J, Yoshida T, Nakaki F, Hiai H, Okazaki T, Honjo T. Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. Proc Natl Acad Sci U S A 2005, 102:11823-11828.


地址:中国广州市番禺区广州大学城华南理工大学B2大楼

邮编:510006

电话(Tel):+86(0)20 39380988(办公室) 39380270(招生) 电子邮箱:scutyxy@scut.edu.cn

2009-2014 © 华南理工大学 医学院 版权所有