Anna Czarna 华南理工大学硕士生导师

Co-PI

Anna Czarna  特聘副研究员   

华南理工大学硕士生导师        


电子邮箱:annaczarna@scut.edu.cn

教育/工作经历

2018-至今,华南理工大学,特聘副研究员

2016-2017,瑞士再生医学研究所,研究员

2012-2015,美国哈佛大学医学院,博士后

2010-2012,德国马克思普朗克生物化学研究所,博士后

2006-2009,德国慕尼黑工业大学,生物化学/化学,博士

2001-2006,波兰雅盖隆大学,生物学(生物化学),硕士

科研方向

干细胞生物学

科研成果

目前的研究重点在于寻找治疗如糖尿病这样的威胁健康疾病的最佳方法,主要兴趣是促进药物发现、干细胞生物学、基因编辑、纳米技术和再生医学,近5年已在医学和生物领域著名期刊上发表SCI论文共5篇,其中第一作者2篇,文章具有很高的影响力,被Cell等国际权威杂志广泛引用和报道。具有生物化学、干细胞生物学、基因编辑、纳米技术和再生医学等多学科交叉研究背景,在糖尿病方面的研究工作也具备很强的创新性和应用潜力。其促进药物发现、干细胞生物学、基因编辑和纳米技术的交叉研究作为再生医学的独特有效治疗工具对于临床医疗具有重要意义,有望在临床治疗方面取得更有效的进展。

个人代表论文

1. Czarna, A., Beck, B., Srivastava, S., Popowicz, G., Wolf, S., Huang, Y., Bista, M., Holak, T. and Dömling, A. (2010). Robust Generation of Lead Compounds for Protein-Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists. Angewandte Chemie International Edition, 49(31), pp.5352-5356.

2. Czarna, A., Berndt, A., Singh, H., Grudziecki, A., Ladurner, A., Timinszky, G., Kramer, A. and Wolf, E. (2013). Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function. Cell, 153(6), pp.1394-1405.

3. Czarna, A., Breitkreuz, H., Mahrenholz, C., Arens, J., Strauss, H. and Wolf, E. (2011). Quantitative Analyses of Cryptochrome-mBMAL1 Interactions. Journal of Biological Chemistry, 286(25), pp.22414-22425.

4. Czarna, A., Popowicz, G., Pecak, A., Wolf, S., Dubin, G. and Holak, T. (2009). High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle, 8(8), pp.1176-1184.

5. Czarna, A., Sanada, F., Matsuda, A., Kim, J., Signore, S., Pereira, J., Sorrentino, A., Kannappan, R., Cannatà, A., Hosoda, T., Rota, M., Crea, F., Anversa, P. and Leri, A. (2017). Single-cell analysis of the fate of c-kit-positive bone marrow cells. npj Regenerative Medicine, 2(1).

6. Kannappan, R., Matsuda, A., Ferreira-Martins, J., Zhang, E., Palano, G., Czarna, A., Cabral-Da-Silva, M., Bastos-Carvalho, A., Sanada, F., Ide, N., Rota, M., Blasco, M., Serrano, M., Anversa, P. and Leri, A. (2017). p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo. EBioMedicine, 16, pp.224-237.

7. Kannappan, R., Matsuda, A., Ferreira-Martins, J., Zhang, E., Palano, G., Czarna, A., Cabral-Da-Silva, M., Bastos-Carvalho, A., Sanada, F., Ide, N., Rota, M., Blasco, M., Serrano, M., Anversa, P. and Leri, A. (2017). p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo. EBioMedicine, 16, pp.224-237.

8. Popowicz, G., Czarna, A., Wolf, S., Wang, K., Wang, W., Dömling, A. and Holak, T. (2010). Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle, 9(6), pp.1104-1111.

9. Sanada, F., Kim, J., Czarna, A., Chan, N., Signore, S., Ogórek, B., Isobe, K., Wybieralska, E., Borghetti, G., Pesapane, A., Sorrentino, A., Mangano, E., Cappetta, D., Mangiaracina, C., Ricciardi, M., Cimini, M., Ifedigbo, E., Perrella, M., Goichberg, P., Choi, A., Kajstura, J., Hosoda, T., Rota, M., Anversa, P. and Leri, A. (2014). c-Kit–Positive Cardiac Stem Cells Nested in Hypoxic Niches Are Activated by Stem Cell Factor Reversing the Aging Myopathy. Circulation Research, 114(1), pp.41-55.

10. Srivastava, S., Beck, B., Wang, W., Czarna, A., Holak, T. and Dömling, A. (2009). Rapid and Efficient Hydrophilicity Tuning of p53/mdm2 Antagonists. Journal of Combinatorial Chemistry, 11(4), pp.631-639.

11. Wang, F., Zhang, H., Czarna, A., Chen, W., Yang, B. and Wang, Y. (2018). Function of C-terminal peptides on enzymatic and interfacial adsorption properties of lipase from Gibberella zeae. Biochimica et Biophysica Acta (BBA) - General Subjects, 1862(12), pp.2623-2631.

12. Dubin, G., Stec-Niemczyk, J., Kisielewska, M., Pustelny, K., Popowicz, G., Bista, M., Kantyka, T., Boulware, K., Stennicke, H., Czarna, A., Phopaisarn, M., Daugherty, P., Thøgersen, I., Enghild, J., Thornberry, N., Dubin, A. and Potempa, J. (2008). Enzymatic Activity of the Staphylococcus aureus SplB Serine Protease is Induced by Substrates Containing the Sequence Trp-Glu-Leu-Gln. Journal of Molecular Biology, 379(2), pp.343-356.

13. Popowicz, G., Czarna, A. and Holak, T. (2008). Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle, 7(15), pp.2441-2443.

14. Popowicz, G., Czarna, A., Rothweiler, U., Szwagierczak, A., Krajewski, M., Weber, L. and Holak, T. (2007). Molecular Basis for the Inhibition of p53 by Mdmx. Cell Cycle, 6(19), pp.2386-2392.

15. Popowicz, G., Dubin, G., Stec-Niemczyk, J., Czarna, A., Dubin, A., Potempa, J. and Holak, T. (2006). Functional and Structural Characterization of Spl Proteases from Staphylococcus aureus. Journal of Molecular Biology, 358(1), pp.270-279.

16. Rothweiler, U., Czarna, A., Krajewski, M., Ciombor, J., Kalinski, C., Khazak, V., Ross, G., Skobeleva, N., Weber, L. and Holak, T. (2008). Isoquinolin‐1‐one Inhibitors of the MDM2–p53 Interaction. ChemMedChem, 3(7), pp.1118-1128.

17. Rothweiler, U., Czarna, A., Weber, L., Popowicz, G., Brongel, K., Kowalska, K., Orth, M., Stemmann, O. and Holak, T. (2008). NMR Screening for Lead Compounds Using Tryptophan-Mutated Proteins. Journal of Medicinal Chemistry, 51(16), pp.5035-5042.

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