孙林冲 华南理工大学硕士生导师

Co-PI

孙林冲特聘副研究员

华南理工大学硕士生导师


电子邮箱:sunlc@scut.edu.cn


教育/工作经历

2017-至今,华南理工大学特聘副研究员

2016-2017,中国科学技术大学,生命科学学院助理研究员

2010-2016,中国科学技术大学,细胞生物学博士

2006-2010,新乡医学院,生物技术专业,学士

科研成果

研究成果主要发表于Cell Research, eLife, JCI, Nature Communication, EMBO Reports, Cell Reports等杂志。担任助理研究员期间获得国家自然科学基金青年基金资助。

科研方向

肿瘤微环境与能量代谢研究

个人代表论文

1.  Sun, L.C., Suo, C.X., Li, S.T., Zhang, H.F.*, Gao, P.* (2018). Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect. Biochimica et biophysica acta, Reviews on Cancer (Online)

2. Sun, L.C., and Gao, P.* (2017). Small molecules remain on target for c-Myc. Elife 6. e22915

3. Sun, L.C., Song, L.B., Wan, Q.F., Wu, G.W., Li, X.H., Wang, Y.H., Wang, J., Liu, Z.J., Zhong, X.Y., He, X.P., Shen, S. Q., Pan, X., Li, A. L., Wang, Y. L.,Gao, P.*, Tang, H. R.*, Zhang, H. F.* (2015). cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Research 25, 429-444.

4. Sun, L.C., He, X.P., Cao, Y., Gao, P.*, and Zhang, H.* (2014). MicroRNAs and energy metabolism in cancer cells. In MicroRNAs: Key Regulators of Oncogenesis (Springer), pp. 83-95.

5. Wu, G.W., Yuan, M.Q., Shen, S.Q., Ma, X.Y., Fang, J.W., Zhu, L.B., Sun, L.C., Liu, Z.J., He, X.P., Huang, D., Li, T.T., Li, C.C., Wu, J., Hu, X., Li, Z.Y., Song, L.B., Qu, K., Zhang, H.F.*, Gao, P.* (2017). Menin enhances c-Myc-mediated transcription to promote cancer progression. Nature communications 8

6. Ma, X. Y., Wang, L., Huang, D., Li, Y. Y., Yang, D. D., Li, T. T., Li, F. D., Sun, L. C., Wei, H. R., He, K., Yu, F. Z., Zhao, D. B., Hu, L., Xing, S. G., Liu, Z. J., Li, K., Guo, J., Yang, Z. Y., Pan, X., Li, A. L., Shi, Y. Y., Wang, J. F., Gao, P.*, Zhang, H. F.* (2017). Polo-like Kinase 1 Coordinates Biosynthesis during Cell Cycle Progression by Directly activating pentose phosphate pathway. Nature Communications 8(1):1506.

7. Zhong, X.Y., Tian, S.Y., Zhang, X., Diao, X.W., Dong, F.T., Yang, J., Li, Z.Y., Sun, L.C., Wang, L., He, X.P., Wu, G.W., Hu, X., Wang, L.H., Song, L.B., Zhang, H.F., Pan, X., Li, A.L.*, Gao, P.* (2017). CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis. EMBO Rep 18, 809-825.

8. Xiang, Y., Stine, Z. E., Xia, J. S., Lu, Y. Q., O'Connor, R. S., Altman, B. J., Hsieh, A. L., Gouw, A. M., Thomas, A. G., Gao, P., Sun, L. C., Song, L. B., Yan, B., Slusher, B. S., Zhuo, J. L., Ooi, L. L., Lee, C. G. L., Mancuso, A., McCallion, A. S., Le, A., Milone, M. C., Rayport, S., Felsher, D. W., Dang, C. V.* (2015). Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. Journal of Clinical Investigation 125, 2293-2306.

9. Ma, X.Y., Li, C.C., Sun, L.C., Huang, D., Li, T.T., He, X.P., Wu, G.W., Yang, Z., Zhong, X.Y., Song, L.B., Gao, P.*, Zhang, H.F.* (2014). Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature communications 5.

10. Huang, D., Li, T. T., Li, X. H., Zhang, L., Sun, L. C., He, X. P., Zhong, X. Y., Jia, D. Y., Song, L. B., Semenza, G. L., Gao, P., Zhang, H.F.* (2014) HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. Cell reports 8, 1930-1942

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