“Global Forum for Excellent Young Scholar” by South China University of Technology
 
time: 2017-05-15

Dear teachers and fellow students,

        “Global Forum for Excellent Young Scholar” welcomes young talents with different academic background around the world, to discuss frontier and hot research topics with the hope of creating a platform for both SCUT and young scholars to promote international exchanges and cooperation.The arrangement of the forum is as below:

 1.Time

    9:00 am,May 18,2017

2.Venue

DongTang Conference Room, Building #13

3.Agenda

     (1)9:00—9:05   Welcome Speech

     (2)9:05—9:35    Speaker:Dr.  Tuo Zhang, Michigan State University.

Title:  Structure and function of a ZIP zinc transporter, a central player in zinc metabolism



Contents:

Zinc is the second most abundant essential microminerals (after iron) in humans, and 10% of proteins (~3000 proteins) encoded by human genome are predicted to be zinc binding proteins.According to the WHO, as high as 31% of people around the world are at risk of zinc deficiency. However, as a transition metal, excess zinc is toxic. Accordingly, a sophisticated control of systemic and cellular zinc homeostasis is vital for life. In human, two zinc transporter families play central roles in zinc homeostasis: Zrt/Irt-like protein (ZIP, SLC39) family and ZnT (SLC30) family are responsible for zinc influx and efflux across cell membrane, respectively. A total of fourteen ZIP proteins have been identified with diverse tissue/cellular distribution in human, which are broadly associated with a variety of human diseases. In this talk I will present the structural and functional results of a mammalian ZIP transporter extracellular domain (pZIP4-ECD) and a highly conserved transmembrane domain from bacterial (BbZIP). ZIP4-ECD reveals two structurally independent subdomains and an unprecedented dimer centred at the signature PAL motif. The BbZIP structure reveal two metals forms a binuclear metal center in the transport pathway.



     (3)9:35—10:00   Speaker:Dr. Rongrong Liu, Nanyang Technological University.

 Title:   Biosensors for enzyme detection and single molecule imaging of biomacromolecules



Contents:

Biomolecule detection plays an important role in the fields of medical diagnosis, environmental monitoring and food safety. It has driven the increasing demand for developing simple, ultrasensitive and cost effective biosensors. With the rapid development of nanotechnology, nanomaterial-based biosensing platforms have emerged on the basis of their unique optical, electronic and catalytic properties.  By coupling nanomaterial with biomolecular recognition events, the first gold nanoparticles based biosensor for sensing beta-lactamases and screening their inhibitors will be presented in this talk. Sequential sensing multiple enzymes and reversible manipulation of nanostructures with specific interactions will also be discussed. In this talk, Dr Liu will introduce the fluorescence imaging of biomacromolecuesby using single molecule technique. Imaging of single conjugated polymer nanodots (CPNs) and their superior optical features will be demonstrated.



       Welcome to attend!