2019 绿色低碳合成国际研讨会 发布者:魏巍   发布时间:2019-10-23   浏览次数:1000

时间:20191028日(星期一)8:30-13:00

报告地点:化学与化工学院逸夫工程馆四楼会议室

  欢迎广大师生前往参加

华南理工大学化学与化工学院

广东省功能分子工程重点实验室

20191023

报告1题目:Green Catalytic cross-couplings from CH bondsfor fast modifications of P and N ligands    (C-H键的绿色催化交叉偶用于氮膦配体的快速修饰)

报告人: Pierre. H. Dixneuf教授(法国雷恩一大)

报告时间:8:40—9:25

AbstractRuthenium(II) catalysts associated to a carboxylate   partner are able to promote the selective sp2 CH bond activation of functional arenes and heterocycles to selectively   lead to cross-couplings with  hetero(aryl) halides. It is possible now   to perform such processes in water in a greener and more sustainable way   without surfactant and with higher catalyst activity. The lecture will present   several new aspects based on these activation principles.(1)Catalytic sp2 CH bond activation/functionalization in water can be   directed to produce polyheterocycles ligands and Hexaheteroarylbenzenes, with   potential as polydentate ligands and for photocatalysis. (2) C(sp3) –H bond functionalization of alkyl goups linked to   heterocycles are selectively achieved using simple copper catalysts and in   situ generated radicals. (3)   Ruthenium-catalyzed alkylations of ortho CH bonds of phosphine oxides with alkenes can give access to new   bifunctional phosphines. (4)   Rhodium(I) catalyst can regioselectively   functionalize the biaryl group of phosphines at o’ position via formal   insertion of alkene to produce functional dialkylated phosphines. (5) The later can be used for efficient carboxylation of arylbromides with CO2.   And help of photocatalyst.These green catalytic processes offer new routes for   the building of polyfunctional ligands which have potential for the creation   of efficient catalysts and for the design of new photoredox systems.

报告人简介:Pierre H.   Dixneuf19961999年间任法国国家科学研究中心(CNRS)化学部副主任,2000年后连续三年担任雷恩大学化学院主任,2001年到2004年任雷恩大学副校长,主管科研工作。Dixneuf教授目前为法国大学科学院(the Institut Universitaire de France)院士,并担任多种国际著名化学期刊杂志编委。Dixneuf教授的主要研究领域是羧酸酯的官能化,选择性碳-碳键形成,碳-氢键活化与官能化、烯烃移位反应与复分解反应等的合成方法学。到目前为止,他共计在Nat. Chem., J.   Am. Chem. Soc., Angew. Chem. Int. Ed.等国际高水平期刊上发表论文460余篇、参与编写著作18部、个人专著4部、拥有6项国际专利;获得的奖项主要包括1990年洪堡奖、1994年法国科学奖、2001年德国化学会格林雅-维帝希奖、2006年获意大利Sacconi 奖章、Grand prix IFP科学技术奖以及2014年第一个由中国化学会颁发的法国化学家奖等。

报告2题目:Precious Catalysis with   Non-Noble Metal Catalysts(非贵金属的高值化催化)

报告人:Matthias   Beller教授(德国罗斯托克大学莱布尼兹催化研究所)

报告时间:9:25—10:10

AbstractThe cost-effective and waste-free synthesis of materials, life science   goods and all kinds of organic products require efficient chemical   transformations. In this regard, development of more active and selective   catalysts constitutes a key factor for achieving improved processes and   providing the basis for sustainable chemical industry. Despite continuous   advancements in all areas of catalysis, still organic syntheses as well as   the industrial production of most chemicals can be improved significantly in terms   of sustainability and efficiency. In the talk, it will be shown how new and   improved homogeneous and heterogeneous catalysts can be developed by learning   from each other. Specifically, the phenomenon of cooperative catalysis will   be addressed in the context of non-noble metal-based catalysts. In detail, it   will be demonstrated that recently developed molecular-defined as well as   nano-structured cobalt and iron catalysts enable catalytic (de)hydrogenation   processes with high yields and unprecedented selectivity. Examples which   demonstrate the potential of such catalytic processes with bio-relevant metal   complexes compared to more traditional catalytic reactions will also include   reactions for energy technologies.

报告人简介:Beller教授为德国科学院院士、莱布尼茨催化所所长和莱布尼茨催化协会副主席,在世界科学界享有广泛的威望和影响。他主要致力于化学催化研究(包括均相催化和非均相催化),重点关注能源问题和工业生产中的大众化学品合成问题。截至20197月份,他已在Science 4篇),Nature1篇)、Nature Chem2篇)、Nat. Catal.7篇)、Nat. Commun. (11)Chem. Rev. (5)Chem. Soc.   Rev. (5)Acc. Chem. Res   (2)J. Am. Chem.   Soc.36篇)、Angew. Chem. Int.   Ed.140篇)等国际高水平期刊上发表学术论文1200余篇,论文累计被引用64000余次,个人H因子131;申请德国、欧洲和国际专利100多项;多次获得欧洲可持续化学奖、亚历山大洪堡奖、德意志联邦共和国勋章等大奖。Beller教授除了在学术届享有极高的声誉外,在欧洲工业届也有着很大的影响力,很多知名企业,如Evonik, NovartisBASF,    DSM等都和Beller教授有着深入的合作,众多科研成果实现了产业化。此外,Beller教授还具有丰富的国际合作经验和非常强的行政管理能力,为世界各地的科研单位和企业输送了大量优秀科研人才。

报告3题目:Site-Specific and Enantioselective Cyanation of Sp3   CH Bonds(Sp3碳氢键的位点和对映选择性腈基化)

报告人:Prof. Guosheng   Liu(刘国生)教授(中国科学院上海有机化学研究所金属有机国家重点实验室)

报告时间:10:10—10:55

AbstractDue to the highly active radical intermediate, the organic   transformations via radical pathway have been extensively studied. However,   the selective control of radical intermediate is extremely challenging, which   significantly retards the success of highly selective radical reaction, especially   for the enantioselective version. Recently, Our group recently reveals that   the stereoselective control of radical could be achieved by using copper   catalyst, and a series of enantioselective difunctionalization of alkenes   have been explored by using bisoxazoline (Box)/Cu(I) catalytic system, such   as trifluoromethylcyanation, aminocyanation, trifluoromethylarylation. In   these studies, a benzylic radical intermediate was involved in the catalytic   cycles, which can be enantioselectively trapped by (Box)/CuII   intermediate to produce enantiomerically enriched products. Inspired these   results, we disclosed a radical delay process for the successful asymmetric   oxidative cyanation of benzylic CH bond by using copper catalyst,   which presented one of most efficient method for the efficient synthesis of   optical pure alkylnitriles from simple alkyl arenes. Very recently, a   site-specific and enantioselective allylic CH cyanation was disclosed by an unprecedented copper-bound   N-centered radicals, which will be presented as well.

报告人简介:刘国生教授为国家自然科学杰出青年基金、中科院百人计划获得者。他1995年本科毕业于南京理工大学、2002年在中科院上海有机化学研究所获得博士学位、2003年至2007年间分别在美国理海大学和威斯康星大学从事博士后研究;2007年至今担任中科院上海有机化学研究所的教授、同时兼任华东师范大学教授。他先后获得了德国洪堡奖、BASF青年创新知识奖、上海市领军学术带头人等诸多奖项。至今,他已在Science1篇),Nature1篇)、Nat. Chem.2篇)、Acc. Chem. Res   (2)J. Am. Chem.   Soc. (18), Angew.   Chem. Int. Ed. (18) 等国际高水平期刊上发表学术论文90余篇、参编专著6部、获授权专利7项。

报告4题目:Asymmetric Hydrogenation Using Chiral   Tridentate Ligands(三齿配体参与的不对称氢化)

报告人:Prof. Xumu   Zhang(张绪穆)教授(南方科技大学化学系)

报告时间:11:15—12:00

AbstractCatalytic asymmetric hydrogenation of prochiral   ketones is a convenient and economical method to prepare chiral alcohols,   which are significant building blocks in pharmaceuticals and natural   products. Since Noyori’s milestone work in the 1990s wherein the BINAP-ruthenium-diamine   catalytic system was originally developed for hydrogenation of ketones,   numerous ligands including bidentate and tridentate ligands have been   synthesized and investigated in metal catalyzed asymmetric hydrogenation.   Because of the stability and high activity, tridentate ligands have shown   promising potential in ketone reduction. In 1998, we had developed a novel   tridendate NNN ligand (ambox)   which had been successfully used in asymmetric transfer hydrogenation of   ketones, which represents the first application of a tridendate ligand in   asymmetric (transfer) hydrogenation.[1] Since   then, chiral tridendate ligands have attracted increasing attention in highly   efficient and enantioselective ketone hydrogenation. In 2010, indan-ambox, a derivative of ambox, had been applied in asymmetric   hydrogenation of ketones with excellent enantiocontrol albeit with low   efficiency.[2] To solve the efficiency problem, our group has   recently developed a series of ferrocene-based tridentate ligands, f-amphox, [3]f-amphol,[4]f-ampha,[5] and f-amphamide, [6] which had shown super activity in iridium-catalyzed asymmetric hydrogenation   of ketones (TONs up to 1000000). Compared to Noyori’s BINAP-ruthenium-diamine   catalytic system, iridium (III)-hydride complex ligated with theses   tridentate ligands have several features, including (1) extreme stability   because of d6 configuration of Ir (III); (2) extreme activity because of the   two Ir-H trans effect; (3) devoid of product inhibition due to coordinative saturation.

报告人简介:张绪穆教授为中组部特聘专家、教育部长江学者、国家自然科学杰出青年基金获得者,国际知名配位化学和金属有机化学家,现任南方科技大学理学院副院长、化学系讲席教授。他1982年本科毕业于武汉大学、1985年在中科院获得硕士学位、1992年在斯坦福大学获得博士学位。之后,他分别在诺贝尔奖得主GrubbsSharpless课题组从事博士后研究工作。1994年至2006年间在宾夕法尼亚州立大学任终身教授、2007年至2015年间任罗格斯大学杰出教授、2015年至今任职于南方科技大学,现担任化学首席教授、化学系系主任等职务;他先后获得了ACS Arthur C. Cope 学术奖、圣地亚哥华人协会成就奖等奖项。张教授主要从事新型氮、膦配体设计、有机金属化学、药物的绿色合成、不对称催化加氢、不对称加氢甲酰化、线性加氢甲酰化、二氧化碳还原等方面的研究工作,他所发展的张氏烯炔环异构化反应已成为人名翻译,现为两家公司的创始人。至今,他已在J. Am. Chem.   Soc.Angew. Chem.   Int. Ed.等国际高水平期刊上发表学术论文300余篇。

报告5题目:Synthesis of Phosphorus-Containing Ligands   and Their Applications in Asymmetric Catalysis(含膦配体的合成及其在不对称催化中的应用)

报告人:Prof. Liqin   Qiu(邱立勤)教授(中山大学)

报告时间:12:00—12:30

AbstractPhosphorus-containg ligands   are very important in modern organic synthesis and catalysis. In recent   years, we successfully developed several kinds of chiral monophosphine and   phosphoramidite ligands based on chiral-bridged biphenyl backbones and their   applications in palladium-catalyzed asymmetric Suzuki coupling,   iridium-catalyzed asymmetric addition of arylboronic acids to N-protected isatins and   iridium-catalyzed enantioselective intramolecular allylic aminations of   benzimidazole-tethered allylic carbonates with high efficiency. Impressively,   the chiral-bridged biphenyl ligands with tunable dihedral angles exhibited   obvious advantages over the BINOL-derived ligands in these explored   transformations.

报告人简介:邱立勤教授1986年本科毕业于合肥工业大学、1992年在天津大学化工系获硕士学位、2003年在香港理工大学应用生物与化学科技学系获博士学位。他2003年至2007年间在香港理工大学从事博士后研究,2007年至今在中山大学化学院任教授、博导,现任中山大学化学化工学院有机化学研究所所长,广东省化学会理事、有机化学专业委员会副主任、中山大学化学化工学院应用化学系主任。邱教授的研究工作主要集中于手性合成与不对称催化、功能化学品的分子设计与合成、药物及中间体的合成与分离纯化。至今,他已在J. Am. Chem.   Soc.Proc. Natl. Acad. Sci.Org. Lett.等等国际高水平期刊上发表学术论文80余篇、授权专利20余项。