Academic Staff

Professor(Double-hired)

DAN SHAO Professor  Laboratory of Bioactive and Biomimetic Materials


Education and Work Experience:

2019-present  South China University of Technnology Professor

2016-2019  Columbia University, United States Postdoctoral Research Fellow

2006-2015 Jilin University PHD

2006-2010 West China School of Pharmacy, Sichuan University Bachelor

Research Direction:

Laboratory of Immune Biomaterialswas established by Prof. Dan Shao since September 2019. The research in our labis highly multidisciplinary, which integrate materials, medicine, biology andengineering to achieve efficient and safe diagnosis and therapy of inflammatorydiseases. We are specifically interested in the following areas:

 

  • Inflammatory Disease

  • Bioactive Materials

  • Biomimetic Materials

  • Material-bioInteractions

  • Nanomedicine

  • Flashtechnology-based Bio-manufacture

  •  

 

Research Achievement:

Till 2021, Prof. Shao has published more than 80SCI papers in top-tier journals including Nat.Rev. Mater., Sci. Adv., Adv. Mater., Mater. Today, Adv. Funct. Mater., Adv.Sci., ACS Nano, Sig. Transduct. Target Ther., Small, Biomaterials, Theranosticsetc. The total citations are over 3000 times (H=33), while 5 papers arelisted as the ESI highly cited papers and 9 papers are selected as the JournalCover.

Representative Publications

  1. Tu Z, Zhong Y, Hu H, Shao D*, Haag R, SchirnerM, Lee J, Sullenger B, Leong K*. Design of Therapeutic Biomaterials to ControlInflammation. Nature Reviews Materials.2022.

  2. Shi C, Dawulieti J, Shi F, Chao Y, Qian Q, Shi T, Wang L, Hu H, Sun M, RenL, Chen F, Zhao Y, Liu F, Li M, Mu L, Liu D, Shao D*, Leong K*, She J*. Ananoparticulate dual scavenger for targeted therapy of inflammatory boweldisease. Science Advances.2022, 8: eabj2372.

  3. Chen X, Shi T, Yang C*, Chen F, He X, Zhang K, Hu H, Cai L, Leong K*, ShaoD*.Scalable Biomimetic SARS-CoV‑2 Nanovaccines withRobust Protective Immune Responses. Signal Transduction and Targeted Therapy. 2022. In Press

  4. Yang Y, Chen F, Xu N, Yao Q, Wang Y, Xie X, Zhang F, ShaoD*, Dong W, Fan J, Sun W*, Peng X. Red-Light-Triggered Self-DestructiveMesoporous Silica Nanoparticles for Cascade Amplifying Chemo-PhotodynamicTherapy Favoring Antitumor Immune Responses. Biomaterials. 2022, 281: 121368.

  5. Peng J, Chen F*, Liu Y, Zhang F, Chao L, You Q, Yang D, ChangZ, Ge M, Li L, Wang Z, Mei Q, Shao D*, Chen M, Dong W*,Peng X. A light-driven dual-nanotransformer with deep tumor penetration forefficient chemo-immunotherapy. Theranostics. 2022, 12: 1756-1768.(Inside Back Cover)

  6. ZhangF, Chen F, Yang C, Wang L, Hu H, Li X, Zheng X, Wang Z, Chang Z, Li T, Li L, GeM, Du J, Sun W*, Dong W*, Shao D*.Coordination andRedox Dual-Responsive Mesoporous Organosilica Nanoparticles Amplify ImmunogenicCell Death for Cancer Chemoimmunotherapy Small.2021, 17: 2100006. (Inside Front Cover)

  7. Hu H#, Yang C#, Zhang F, Li M, Tu Z, Mu L,Dawulieti J, Lao Y, Xiao Z, Yan H, Sun W, Shao D*, Leong K*. AVersatile and Robust Platform for the Scalable Manufacture of Biomimetic Nanovaccines.Advanced Science. 2021, 8: 2002020.(Inside Back Cover)

  8. Hu H#, Yang C#, Li M, Shao D*, Mao H, Leong K*.Flash technology-based self-assembly in nanoformulation: Fabrication tobiomedical applications. MaterialsToday. 2021, 42: 99-116.

  9. Zheng X#, Jia Y#, Zhao Y#, Shao D*, Zhang F, Sun M,Dawulieti J, Hu H, Cui L, Pan Y, Yang C*, Sun W, Zhang S, He K, Li J, Du J,Zhang M*, Chen L*. Biomimetic co-assembled nanodrug of doxorubicin andberberine suppresses chemotherapy-exacerbated breast cancer metastasis. Biomaterials. 2021, 271: 120716.

  10. Shao D#*, Zhang F#,Chen F#, Zheng X, Hu H, Yang C, Tu Z, Wang Z, Chang Z, Lu J, Li T,Zhang Y, Chen L, Dong W*, Leong K*. Biomimetic Diselenide-Bridged MesoporousOrganosilica Nanoparticles as an X-ray-Responsive Biodegradable Carrier forChemo-Immunotherapy. AdvancedMaterials. 2020, 32: 2004385. (Front Cover)

  11. Dawulieti J, Sun M, Zhao Y, Shao D*, Yan H, Lao Y, HuH, Cui L, Lv X, Liu F, Chi C, Zhang Y, Li M, Zhang M, Tian H, Chen X, Leong K*,Chen L*. Treatment of Severe Sepsis with Nanoparticulate Cell-free DNAScavengers. Science Advances.2020, 6: eaay7148.

  12. Zhang Y, He Y, Shi C, Sun M, YangC*, Li H, Chen F, Chang Z, Zheng X, WangZ, Dong W*, She J, Shao D*. Tannic Acid-Assisted Synthesis ofBiodegradable and Antibacterial Mesoporous Organosilica Nanoparticles Decoratedwith Nanosilver. ACS Sustainable Chem.Eng. 2020, 8, 1695-1702.

  13. Wang Z, Zhang F, Shao D*,Chang Z, Wang L, Hu H, Zheng X, Li X, Chen F, Tu Z, Li M, Sun W*, Chen L, DongW*. Janus NanobulletsCombine Photodynamic Therapy and Magnetic Hyperthermia to Potentiate SynergeticAnti-Metastatic Immunotherapy. AdvancedScience. 2019, 6, 1901690. (Back Cover)(ESI Highly cited paper)

  14. Yan H, Shao D*, Lao Y, Li M, Hu H, Leong K*. Engineering of CellMembrane-based Nanotherapeutics to Target Inflammation. Advanced Science. 2019, 6: 1900605. (Front Cover) (ESIHighly cited paper)

  15. Wang Z, Chang Z, Shao D*, Zhang F, Chen F, Li L, Ge M, Hu R, Zheng X, Wang Y*, Dong W*. Janus Gold Triangle-Mesoporous Silica Nanoplatformsfor Hypoxia-Activated Radio-Chemo-Photothermal Therapy of Liver Cancer. ACS Applied Materials & Interfaces.2019, 11: 34755-34765.

  16. Zhang F, Jia Y,Zheng X, Shao D*, Zhao Y, Wang Z, Dawulieti J, Liu W, Sun M, Sun W,Pan Y, Cui L, Wang Y, He K, Zhang M, Li J*, Dong W*, Chen L*.Janus Nanocarrier-basedCo-delivery of Doxorubicin and Berberine Weakens Chemotherapy-Exacerbated HepatocellularCarcinoma Recurrence. ActaBiomaterialia 2019, 100:352-364.

  17. ShaoD, Li M, Wang Z, Zheng X, LaoY, Chang Z, Zhang F, Lu M, Yue J, Hu H, Yan H, Chen L, Dong W*, Leong K*.Bioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles forDual-Responsive Protein Delivery. AdvancedMaterials. 2018, 30: 1801198. (Front Cover) (ESIHighly cited paper)

  18. Wang Z, Chang Z, Lu M, Shao D*, Yue J, Yang D, Zheng X, LiM, He K, Zhang M, Chen L, Dong W*. Shape-ControlledMagnetic Mesoporous Silica Nanoparticles for Magnetically-Mediated Suicide GeneTherapy of Hepatocellular Carcinoma. Biomaterials. 2018, 154: 147-157.(ESI Highly cited paper)

  19. Chang Z, Wang Z,Shao D*, Yue J, Li Li, Yang D, Li M, Yan H, Hu H, Xu Q,Dong W*. Shape Engineering Boosts Magnetic Mesoporous SilicaNanoparticles-based Isolation and Detection of Circulating Tumor Cells. ACS Applied Materials & Interfaces.2018, 10: 10656-10663.

  20. Zheng X, ZhangF, Zhao Y, Zhang J, Dawulieti J, Pan Y, Cui L, Sun M, Shao D*,Li M, He K, Li J*, Zhang M, Chen L*. Self-assembled Dual FluorescenceNanoparticles for CD44-targeted Delivery of anti-miR-27a in Liver CancerTheranostics. Theranostics2018, 8: 3808-3823.

  21. Wang Z, Shao D*, Chang Z, Lu M, Wang Y, Yang D, Yue J, Li M, Xu Q,Dong W*. Janus Gold Nanoplatform for Synergetic Chemoradiotherapy and ComputedTomography Imaging of Hepatocellular Carcinoma. ACS Nano. 2017,11: 12732-12741.

  22. Wang Z, Chang Z, Lu M, Shao D*, Yue J, Yang D, Li M, Dong W*. Janus Silver/Silica Nanoplatforms forLight-Activated Liver Cancer Chemo/Photothermal Therapy. ACS Applied Materials & Interfaces.2017, 9: 30306-30317.

  23. Shao D#, LuM#, Zhang F, Tan Y, Zhao Y, Zheng X, Pan Y, Xiao X, Wang Z, Dong W*,Li J*, Chen L.The Shape Effect of Magnetic Mesoporous Silica Nanoparticles on Endocytosis,Biocompatibility and Biodistribution. ActaBiomaterialia. 2017,49:531-540.

  24. Chang Z, Wang Z, Shao D*, Yue J, Lu M, Li L,Ge M, Yang D, Li M, Yan H, Xu Q, Dong W*. Fluorescent-Magnetic Janus Nanorodsfor Selective Capture and Rapid Identification of Foodborne Bacteria. Sensors & Actuators: B. Chemical.2018. 260: 1004-1011.  

  25. Shao D#, Li J#, Zheng X, Pan Y, Wang Z, Zhang M, ChenQ, Dong W*, Chen L*. Janus“Nano-Bullets” for Magnetic Targeting Chemotherapy of Liver Cancer. Biomaterials. 2016, 100:118-133.

  26. Shao D#, ZhangX#, Liu W, Zhang F, Zheng X, Qiao P, Li J*, Dong W, Chen L. Janus Silver-Mesoporous Silica Nanocarriers for SERS Traceable andpH-Sensitive Drug Delivery in Cancer Therapy. ACSApplied Materials & Interfaces. 2016, 8: 4303−4308.

  27. Shao D#, Li J#, Xiao X, Zhang M, Pan Y, Li S, Wang Z, Zhang X, Zheng H, Zhang X*, Chen L*. Real-timevisualizing and tracing of HSV-TK/GCV suicide gene therapy by near-infraredfluorescent quantum dots. ACS AppliedMaterials & Interfaces. 2014, 6: 11082-11090.

    Shao D#, Zeng Q#, Fan Z#, Li J, ZhangM, Zhang Y, Li O, Chen L*, Kong X*, Zhang H. Monitoring HSV-TK/ganciclovircancer suicide gene therapy using CdTe/CdS core/shell quantum dots. Biomaterials. 2012, 33:4336-4344.