Name: Han Shuangyan
Title: Professor, Doctor of engineering, Ph.D. supervisor, vice director of Guangdong Provincial Key Laboratory of Fermentation & Enzyme Engineering, dean of Bioengineerng Department
Email: syhan@scut.edu.cn
Education and occupational experience
Education experience
2012.8-2013.8 Visiting scholar, Department of Biological and Agricultural Engineering, University of California, Davis, California, USA
1999.9-2004.7 South China University of Technology, Fermentation Engineering, Ph.D.
1995.9-1999.7 Henan University, Fermentation Engineering, B.A.
Occupational experience
2015.6 to date Ph.D. supervisor, School of Bioscience and Bioengineering, South China University of Technology，Guangzhou, P. R. China
2014.9 to date Professor, School of Bioscience and Bioengineering, South China University of Technology，Guangzhou, P. R. China
2010.7 to date Mastersupervisor, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, P. R. China
2009.12-2014.9 Associate Professor, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, P. R. China
Research fields and main achievements
·Research fields
The research fields are mainly focused on fermentation engineering, enzyme engineering, biocatalysis and so on. Based on the above research, the following 3 aspects are included: 1) to apply metabolic engineering to perform microbial strains modification, especially the enhancement of the host and high expression strain, 2) to use gene engineering technology to produce industrial enzymes & antimicrobial peptides in Pichia pastoris expression system, 3) to utilize yeast surface display to immobilize enzyme and apply the displaying enzyme to produce the high added value chemicals with biological manufacturing.
Main achievements
I have been presided over more than ten research projects supported by National Natural Science Foundation idedof China (NSFC), sub-projects by National Key Technology Research and Development Program of the Ministry of Science and Technology of China, Natural Science Foundation of Guangdong Province，Key scientific and technological projects in Guangdong Province, Fundamental Research Funds for the Central Universities and Enterprises. As the first author or corresponding author, more than ten articles have been published in the SCI journals related to fermentation engineering and bioengineering field, such as Applied Microbiology & Biotechnology，Plos one，Process Biochemistry，Enzyme Microbiology Technology and so on.
I also obtained more than ten authorized patents, as well as obtained the second prize of 2005th scientific and technological progress in Guangdong Province, ranked second. Besides, over ten doctors or masters were trained.
Representative research projects
1.Natural science foundation of Guangdong province project (No. 2015A030313230) : Mechanism of cell wall modification on cell surface display of Pichia pastoris cells ,2015-2018, Principal Investigator
2.Key project of fundamental research funds for the central universities ( 2015ZZ109): Affection of cell wall modification on cell surface display of Pichia pastoris，2015-2017，Principal Investigator
3.Sub-projects supported by National Key Technology Research and Development Program of the Ministry of Science and Technology of China（2012AA022205）: Development biological enzyme applied in organic chemical and biochemical engineering processing new technology，2012-2015，Principal Investigator
4.Key scientific and technological projects in Guangdong Province（2012B010300008）:Application of new displaying lipase RML to produce OPO，2013-2015，Principal Investigator
5.National Natural Science Foundation of China（30900017）: Mechanism of coexistence of two types of anchor and secretion of Candida Antarctica lipase B displayed on the cell surface，2010-2013，Principal Investigator
6.Key project of fundamental research funds for the central universities（2012ZZ0092）: Yeast surface displaying lipase RML to produce OPO，2012-2013，Principal Investigator
7.Business cooperation projects: Antibacterial peptides expressed in Saccharomyces cerevisiae, 2013-2014，Principal Investigator
Representative publications
1 Deng T, Lu LL, Gao SP, Lin Y and Han SY*.Endoglucanase enzymatic modification of kraft pulp during recycling. Biotechnology Letters, 2016, 38(7): 1139-45
2 Jin Z, Han SY, Zhang L, Zheng SP, Wang Y, Lin Y. Combined utilization of lipase-displaying Pichia pastoris whole-cell biocatalysts to improve biodiesel production in co-solvent media. Bioresource technology2013, 130: 102-109
3 Zhang JH, Jiang YY, Lin Y, Sun YF, Zheng SP, and Han SY* . Structure-Guided Modification of Rhizomucor miehei Lipase for Production of Structured Lipids. PloS ONE, 2013, 8(7): e67892
4 Zhao XL, Xie WY, Lin Y, Lin XQ, Zheng SP, and Han SY*. Combined strategies for improving the heterologous expression of an alkaline lipase from Acinetobacter radioresistens CMC-1 in Pichia pastoris. Process Biochemistry, 2013, 48: 1317-1323
5Liang XX, Wang BB, Sun YF, Lin Y, Han SY*. Quantitative evaluation of Candia antarctica lipase B displayed on the cell surface of a Pichia pastoris based on an FS anchor system. Biotechnology letters, 2013, 35(3): 367-74
6 Lin XQ, Han SY, Zhang N, Hu H, Zheng SP, Ye YR, Lin Y. Bleach boosting effect of xylanase A from Bacillus halodurans C-125 in ECF bleaching of wheat straw pulp. Enzyme and microbial technology, 2013, 52: 91-98
7 Sun YF, Lin Y, Zhang JH, Zheng SP, Ye YR, Liang XX, and Han SY*. Double Candida antarctica lipase B co-display on Pichia pastoris cell surface based on a self-processing foot-and-mouth disease virus 2A peptide. Applied Microbiology and Biotechnology, 2012, 96(6): 1539-50
8 Zhang JH, Lin Y, Sun YF, Ye YR, Zheng SP, and Han SY*. High-throughput screening of B factor saturation mutated Rhizomucor miehei lipase thermostability based on synthetic reaction. Enzyme and Microbial Technology, 2012, 50(6-7): 35-330
9 Huang DF, Han SY, Han ZL, Lin Y. Biodiesel production catalyzed by Rhizomucor miehei lipase-displaying Pichia pastoris whole cells in an isooctane system. Biochemical Engineering Journal, 2012, 63: 10-14
10 Jin Z, Ntwali J, Han SY, Zheng SP, Lin Y. Production of flavor esters catalyzed by CALB-displaying Pichia pastoris whole-cells in a batch reactor. Journal of biotechnology, 2012, 159: 108-114
Scientific awards
2005th Second prize of scientific and technological progress in Guangdong Province (rank second)
