您好,欢迎访问分子科学与工程学院!

副教授
王辉
发布时间:2017-02-10        浏览次数:992

性别:男

职称:特聘副研究员,硕士生导师

招生专业:

学术硕士:软物质材料

邮箱:



学习及工作经历

2018-今:    华南理工大学,华南软物质科学与技术高等研究院,特聘副研究员。研究方向,纳米医学与生物材料

2017-2018年:华东师范大学,生命科学学院,专任副研究员

2014-2017年: 中国人民解放军第二军医大学附属长征医院,博士后研究助理

2011-2014年: 华东师范大学, 生命科学学院,纳米材料与生物医学实验室,博士

2008-2011年: 中国科学技术大学, 化学系,功能膜实验室,硕士

2004-2008年: 安徽大学, 化学与化工学院, 学士

研究方向

1.通过超分子策略构建多维聚合物和纳米材料

2.发展纳米药物运输系统用于肿瘤治疗

3.发展高分子基因递送系统

发表学术论文

自研究工作以来主要从事高分子聚合物材料在生物材料领域的应用研究,研究其作为运输载体在药物及基因运输方面的应用,先后在Angewandte Chemie International Edition, Journal of the American Chemical Society等国际权威杂志发表相关研究论文17篇,其中第一作者10篇,通讯作者1篇。

1) Wang H, Wang Y, Wang Y, Hu J, Li T, Liu H, Zhang Q, Cheng Y. Self-assembled fluorodendrimers combine the features of lipid and polymeric vectors in gene delivery. Angewandte Chemie International Edition,2015, 54, 11647-11651. 

2) Liu H†, Wang H†, Yang W, Cheng Y. Disulfide cross-linked low generation dendrimers with high gene transfection efficacy, low cytotoxicity, and low cost. Journal of the American Chemical Society, 2012, 134, 17680-1768. (†共同第一作者)    

3) Wang H, Miao W, Wang F, Cheng Y. A Self-Assembled Coumarin-Anchored Dendrimer for Efficient Gene Delivery and Light-Responsive Drug Delivery. Biomacromolecules, 2018, 19, 2194-2201.

4) Wang H, Chang H, Zhang Q, Cheng Y. Fabrication of Low-Generation Dendrimers into Nanostructures for Efficient and Nontoxic Gene Delivery. Topics in Current Chemistry. 2017, 375, 62.

5) Shen W†, Wang H†, Ling-Hu Y, Lv J, Chang H, Cheng Y. Screening of efficient polymers for siRNA delivery in a library of hydrophobically modified polyethyleneimines. Journal of Materials Chemistry B, 2016, 4, 6468-6474. (†共同第一作者)

6) Shen W, Liu H, Ling-Hu Y, Wang H*, Cheng Y*. Enhanced siRNA delivery of a cyclododecylated dendrimer compared to its linear derivative. Journal of Materials Chemistry B, 2016, 4, 5654-5658. (共同通讯作者)

7) Wang H, Hu J, Cai X, Xiao J, Cheng Y. Self-assembled fluorodendrimers in the co-delivery of fluorinated drugs and therapeutic genes. Polymer Chemistry, 2016, 7, 2319-2322. 

8) Wang H, Huang Q, Chang H, Xiao J, Cheng Y. Stimuli-responsive dendrimers in drug delivery. Biomaterials Science, 2016, 4, 375-390.

9) Wang H, Wei H, Huang Q, Liu H, Hu J, Cheng Y, Xiao J. Nucleobase-modified dendrimers as nonviral vectors for efficient and low cytotoxic gene delivery. Colloids and Surfaces B-Biointerfaces, 2015, 136, 1148-1155. 

10) Wang H, Shao N, Qiao S, Cheng Y. Host-guest chemistry of dendrimer-cyclodextrin conjugates: selective encapsulations of guests within dendrimer or cyclodextrin cavities revealed by NOE NMR techniques. Journal of Physical Chemistry B, 2012, 116, 11217. 

11) Wang H, Wu C, Wu Y, Luo J, Xu T. Cation exchange hybrid membranes based on PVA for alkali recovery through diffusion Dialysis. Journal of Membrane Science, 2011, 376, 233-240. 

12) Zheng Z, Hu J, Wang H, Huang J, Yu Y, Zhang Q, Cheng Y. Dynamic Softening or Stiffening a Supramolecular Hydrogel by Ultraviolet or Near-Infrared Light. ACS Applied Materials & Interfaces, 2017, 9, 24511-24517.

13) Chang H, Zhang J, Wang H, Lv J, Cheng Y. A Combination of Guanidyl and Phenyl Groups on a Dendrimer Enables Efficient siRNA and DNA Delivery. Biomacromolecules. 2017, 18, 2371-2378.

14) Liu H, Chang H, Lv J, Jiang C, Li Z, Wang F, Wang H, Wang M, Liu C, Wang X, Shao N, He B, Shen W, Zhang Q, Cheng Y. Screening of efficient siRNA carriers in a library of surface-engineered dendrimers. Scientific Reports, 2016, 6, 25069. 

15) Shao N, Wang H, He B, Wang Y, Xiao J, Wang Y, Zhang Q, Li Y, Cheng Y. Hydrogen-bonding dramatically modulates the gene transfection efficacy of surface-engineered dendrimers. Biomaterials Science, 2015, 3 500-508. 

16) Wang F, Wang Y, Wang H, Shao N, Chen Y, Cheng Y. Synergistic effect of amino acids modified on dendrimer surface in gene delivery. Biomaterials, 2014, 35, 9187-9198. 

17) Chang H, Wang H, Shao N, Wang M, Wang X, Cheng Y. Surface-engineered dendrimers with a diaminododecane core achieve efficient gene transfection and low cytotoxicity. Bioconjugate Chemistry, 2014, 25, 342-350. 

会议论文

1) Wang H, Miao W, Song D, Cheng Y, Xiao. A light-responsive polymer for the co-delivery of anticancer drugs and therapeutic genes. Journal of Controlled Release, 2017, 259, e49.

2) Wang H, Cheng Y. Self-assembled fluorodendrimers for the co-delivery of fluorine-containing drugs and siRNA. Nanomedicine: Nanotechnology Biology and Medicine, 2016, 12, e550.

3) Wang H, Wang Y, Liu H, Zhang Q, Cheng Y. Self-assembled fluorodendrimers allow efficient transfection with ultra-low DNA dose. Journal of Controlled Release, 2015, 213, e42.


专利

1) 王辉,程义云,一种基于核酸碱基衍生物的高分子基因转染载体及其制备方法与应用,申请号:CN201410037597.7

2) 程义云,王铭明,刘红梅,王辉,常虹,一种含氟脂肪链修饰的阳离子聚合物及其作为基因载体的用途,申请号 : CN201410222864.8


欢迎高分子、化学、物理、生物、材料等相关专业的同学加入团队

地址:中国广东省广州市番禺区华南理工大学国际校区  

版权:华南理工大学分子科学与工程学院