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副教授、副研究员、高级工程师
于倩倩
发布时间:2017-02-07        浏览次数:1882

性别:女

职称:副教授,特聘副研究员,硕士生导师

招生专业:

学术硕士:软物质材料

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教育背景

2016/07 – 2018/07  暨南大学,生命科学技术学院,博士后

2010/09 – 2016/07  暨南大学,生命科学技术学院,博士

2006/09 – 2010/07  周口师范学院,化学化工学院,学士

科研工作经历

2018/03 - 至今    华南理工大学,华南软物质科学与技术高等研究院,王林格教授团队,特聘副研究员。

研究方向:功能高分子材料的制备及其在生物医药领域的应用。

2016/07 - 2018/07  暨南大学,生命科学技术学院,博士后,导师:欧阳健明教授。

研究方向:新型功能纳米材料在多模态生物成像与疾病联合治疗中的应用。

2013/09 - 2016/07  暨南大学,生命科学技术学院,博士,导师:刘杰教授。

研究方向:无机纳米基因载体的构建及其生物学机制研究。

2010/09 - 2013/06  暨南大学,化学与材料学院,硕士,导师:刘杰教授。

研究方向:钌配合物抗肿瘤机制及其作为识别肿瘤细胞荧光探针的应用研究。

获奖荣誉

2016年  暨南大学优秀博士学位论文

2015年  “博士研究生国家奖学金” 

2014 年  暨南大学优秀博士生攀登计划奖励 

2014年  “博士研究生国家奖学金” 

2012年  “硕士研究生国家奖学金” 

教学与科研情况   

研究方向:功能高分子材料的制备及其在生物医药领域的应用。包括高分子纤维材料、高分子囊泡的合成、性能调控、及功能化修饰,研究其在多模态生物影像、药物输送和疾病诊疗等方面的应用。

主要业绩: 至今在Adv. Funct. Mater, Biomaterials, Nanoscale等国际著名期刊上发表论文27篇,其中第一作者/通讯作者论文8篇;授权专利2项。

发表文章列表

1.Yanan Liu, Litao Ma, Hui Zhou, Qianqian Yu, Xu Chen, Yingyu Zhao, Jie Liu*, Polypeptide nano-Se targeting inflammation and theranostic rheumatoid arthritis by anti-angiogenic and NO activating AMPKα signaling pathway. J. Med. Chem. B, 2018, 6, 3497-3514.

2.Qianqian Yu, Jing Sun, Jianming Ouyang* and Jie Liu*, Mesoporous titanium dioxide nanocarrier with magnetic-targeting and high loading efficiency for dual-modal imaging and photodynamic therapy.J. Med. Chem. B, 2017, 5, 6081-6096.

3.Shuang Zhao#, Qianqian Yu#, Jiali Pan, Yanhui Zhou, Chengwen Cao, Jianming Ouyang*, Jie Liu*, Redox-responsive mesoporous selenium delivery of doxorubicin targets MCF-7 cells and synergistically enhances its anti-tumor activity.Acta. Biomater, 2017, 54, 294–306.

4. Dongdong Sun, Weiwei Zhang, Qianqian Yu, Xu Chen, Meng Xu, Yanhui Zhou, Jie Liu*, Chiral penicillamine-modified selenium nanoparticles enantioselectively inhibit metal-induced amyloid β aggregation for treating alzheimer’s disease.J. Colloid. Interf. Sci, 2017, 505, 1001-1010.

5.Gengjia Chen, Meng Xu, Shuang Zhao, Qianqian Yu, Jie Liu*, A pompon-like RuNPs-based theranostic nanocarrier system with stable photoacoustic imaging characteristic for accurate tumor detection and efficient phototherapy guidance. Acs. App. Mater. Inter, 2017, 9, 33645-33657.

6.Shuang Zhao, Mengmeng Xu, Chengwen Cao, Qianqian Yu, Yanhui Zhou, Jie Liu*, A redox- responsive strategy using mesoporous silica nanoparticles for co-delivery of siRNA and doxorubicin. J. Med. Chem. B, 2017, 5, 6908-6919.

7.Shuang Zhao, Litao Ma, Chengwen Cao, Qianqian Yu, Lanmei Chen, Jie, Liu*, Curcumin-loaded redox response of self-assembled micelles for enhanced antitumor and anti-inflammation efficacy. Int. J. Nanomed, 2017, 12, 2489-2504.

8.Yanhui Zhou, Qianqian Yu, Xiuying Qin, Jie Liu*, Improving the anticancer efficacy of laminin receptor-specific therapeutic ruthenium nanoparticles (RuBB-loaded EGCG-RuNPs) via ROS-dependent apoptosis in SMMC-7721 cells. ACS. App. Mater. Inter, 2016, 8, 15000-15012.

9.Xiaoquan Huang, Xu Chen, Qingchang Chen, Qianqian Yu, Jie Liu*, Investigation of functional selenium nanoparticles as potent antimicrobial agents against superbugs. Acta Biomater, 2016, 30, 397-407.

10.Qingchang Chen#, Qianqian Yu#, Yanan Liu, Jie Liu*, Multifunctional selenium nanoparticles: chiral selectivity of delivering 2 MDR-siRNA for reversal of multidrug resistance and real-time biofluorescence imaging. Nanomed. Nanotechnol,2015, 11, 1773-1784.

11.Wenjing Zheng, Chengwen Cao, Yanan Liu, Qianqian Yu, Chengwen Cao, Chuping Zheng, Dongdong Sun, Jie Liu*, Multifunctional polyamidoamine (PAMAM) modified selenium nanoparticles dual-delivering siRNA and cisplatin to A549/DDP cells for reversal multidrug resistnce. Acta Biomater,2015, 11, 368-380.

12.Dongdong Sun, Yanan Liu, Qianqian Yu, Du Liu, Yanhui Zhou, Jie Liu*, Selective nuclei accumulation of ruthenium(II) complex enantiomers that target G-quadruplex DNA.J. Inorg. Biochem, 2015, 150, 90-99.

13.Xianbo Zhou, Chengwen Cao, Qingchang Chen, Qianqian Yu, Yanan Liu, Tiantian Yin and Jie Liu*, PEG modified graphene oxide loaded with EALYLV peptides for inhibiting the aggregation of hIAPP associated with type-2 diabetes. J. Mater. Chem. B, 2015, 3, 7055-7067.

14.Qianqian Yu, Yanan Liu, Chengwen Cao, and Jie Liu*, The use of pH-sensitive functional selenium nanoparticles shows enhanced in vivo VEGF-siRNA silencing and fluorescence imaging, Nanoscale, 2014, 6, 9279-9290.

15.Qianqian Yu, Yanan Liu, Lei Xu, Chuping Zheng, Fangling Le, Xiuying Qin, Yanyu Liu, and Jie Liu*, Ruthenium(II) polypyridyl complexes: cellular uptake, cell image and apoptosis of HeLa cancer cells induced by double targets. Eur. J. Med. Chem, 2014, 82, 82-95.

16.Jingnan Zhang#, Qianqian Yu#, Qian Li, and Jie Liu*, A ruthenium(II) complex capable of inducing and stabilizing bcl-2 G-quadruplex formation as a potential cancer inhibitor. J. Inorg. Biochem, 2014, 134, 1-11.

17.Chuping Zheng, Jinsheng Wang, Yanan Liu, Qianqian Yu, Ying Liu, Ning Deng*, Jie Liu*, Functional selenium nanoparticles enhanced stem cell osteoblastic differentiation through BMP signaling pathways.Adv. Funct. Mater, 2014, 24, 6872 -6873.

18.Jingnan Zhang, Xianbo Zhou, Qianqian Yu, Licong Yang, Dongdong Sun, Yanhui Zhou, Jie Liu*, Epigallocatechin-3-gallate (EGCG)-stabilized Selenium nanoparticles coated with Tet-1 peptide to reduce amyloid-β aggregation and cytotoxicity. ACS. Appl. Mater. Inter, 2014, 6, 8475-8487.

19.Xiuying Qin, Yanan Liu, Qianqian Yu, Licong Yang, Ying Liu, Yanhui Zhou*, Jie Liu*, Mixed-ligand mononuclear copper(II) complex: crystal structure and anticancer activity. ChemMedChem, 2014, 9, 1665-1671.

20.Dongdong Sun, Yanan Liu, Qianqian Yu, Xiuying Qin, Jie Liu*, Inhibition of tumor growth and vasculature and fluorescence imaging using functionalized rutheniu m-thiol protected selenium nanoparticles.Biomaterials, 2014, 35, 1572-1583.

21.Licong Yang, Jingnan Zhang, Chuan Wang, Xiuying Qin, Qianqian Yu, Yanhui Zhou, Jie Liu*, Interaction between 8-hydroxyquinoline ruthenium(II) complexes and basic fibroblast growth factors (bFGF): inhibiting angiogenesis and tumor growth through erk and akt signaling pathways. Metallomics, 2014, 6, 518-531.

22.Qian Li, Jingnan Zhang, Licong Yang, Qianqian Yu, Jie Liu*, Stabilization of G-quadruplex DNA and inhibition of telomerase activity studies of ruthenium(II) complexes. J. Inorg. Biochem, 2014, 130, 122-129.

23.Qianqian Yu, Yanyu Liu, Jingnan Zhang, Yanhui Zhou*, Jie Liu*. Ruthenium(II) polypyridyl complexes as G-quadruplex inducing and stabilizing ligands in telomeric DNA. Metallomics, 2013, 222-231.

24.Dongdong Sun, Yanan Liu, Qianqian Yu, Yanhui Zhou, Rong Zhang, Xiaojia Chen, An Hong* and Jie Liu*, The effects of luminescent ruthenium(II) polypyridyl functionalized selenium nanoparticles on bFGF-induced angiogenesis and AKT/ERK signaling. Biomaterials, 2013, 34, 171-180.

25.Chuan Wang, Qianqian Yu, Yanyu Liu, Dongdong Sun, Yongchao Huang, Yanhui Zhou, Qianling Zhang*, Jie Liu*, Ruthenium(II) polypyridyl complexes stabilize the bcl-2 promoter quadruplex and induce apoptosis of Hela tumor cells. Biometals, 2013, 26, 387-402.

26.Qianqian Yu, Yanan Liu, Chuan Wang, Dongdong Sun, Xingcheng Yang, Yanyu Liu, and Jie Liu*, Chiral ruthenium(II) polypyridyl complexes: stabilization of G-quadruplex DNA, inhibition of telomerase activity and cellular uptake. PLOS ONE, 2012, 7, e50902.

27.Yanyu Liu, Qianqian Yu, Chuan Wang, Dongdong Sun, Yongchao Huang, Yanhui Zhou, Jie Liu*, Ruthenium (II) complexes binding to human serum albumin and inducing apoptosis of tumor cells. Inorg. Chem. Comm, 2012, 24, 104-109.                    

                                                                       

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地址:中国广东省广州市番禺区华南理工大学国际校区  

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