张珉教授课题组
祝贺谢蓉文章被Chemical Science接收
发布时间: 2021-09-26 浏览次数: 39

祝谢蓉同学在《Chem. Sci.》上发表研究论文

Reductive Electrophilic C-H Alkylation of Quinolines by a Reusable Iridium Nanocatalyst

Rong Xie,a Wenhui Mao,a Huanhuan Jia,a Jialu Sun,a Guangpeng Lu,a Huanfeng Jiang,aMin Zhang*a

ABSTRACT: The incorporation of a coupling step into the reduction of unsaturated systems offers a desirable way for diverse synthesis of functional molecules, but it remains to date a challenge due to the difficulty in controlling the chemoselectivity. Herein, by developing a new heterogeneous iridium catalyst composing of N-Si-doped titanium dioxide support and Ir-nanoparticles (Ir/N-Si-TiO2), we describe its application in reductive electrophilic mono and dialkylations of quinolines with various 2- or 4-functionalized aryl carbonyls or benzyl alcohols by utilizing renewable formic acid as the reductant. This catalytic transformation offers a practical platform for direct access to a vast range of alkyl tetrahydroquinolines (THQs), proceeding with excellent step and atom-efficiency, good substrate scope and functional group tolerance, reusable catalyst and abundantly available feedstocks, and generation of water and carbon dioxide as by-products. The work openes a door to further develop more useful organic transformations under heterogeneous reductive catalysis.

Chem. Sci., 2021, DOI: 10.1039/D1SC02967C